VAAL TRIANGLE - The systemic auto-immune disease, Lupus, is found to be a leading cause of mortality in females. A new study shows that the condition ranks higher than diabetes, HIV, and liver diseases among others. But, even though the condition is being intensely studied, the cause of the disease is not yet known. Health Expert Giulia Criscuolo says unfortunately the specific cause is not known, but there are certain factors that trigger the illness such as the environment, genetics and hormones. According to Criscuolo, woman have 8 times more the chance of getting lupus compared to men.